李建军,王添

• 1:中国农业大学人文与发展学院

摘要(Abstract)：

中国科学家利用新一代基因编辑技术CRISPR首次对人类胚胎基因进行编辑，引发了国内外学者广泛的伦理争辩，这些伦理争辩主要聚焦在与基因编辑技术的安全性关注相关的伦理问题、（代际）权利冲突和社会公平性伦理问题等方面。面对人类胚胎基因编辑研究可能带来巨大的利益诱惑，科学研究者必须坚守科学道德底线，开展负责任的研究和创新。

关键词(KeyWords)： 基因编辑技术;人类胚胎;伦理争辩;负责任的研究和创新

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李建军,王添

参考文献(References)：

• [1] 邱仁宗.人胚基因修饰的科学与伦理对话.健康报,2015-05-08(5).
  [2] Francis S. Collins. Statement on NIH funding of research using gene-editing technologies in human embryos.April 29, 2015. http://www.nih.gov/about-nih/who-we-are/nih-director/statements/statement-nih-funding-research-using-gene-editing-technologies-human-embryos.
  [3] 赵欣,赵迎泽.对话周琪:华盛顿共识.科学通报,2016,61(3):283-284.
  [4] 胡珉琦.改得了基因绕不过伦理.中国科学报,2015-6-05(4).
  [5] Jocelyn Kaiser. The gene editor CRISPR won't fully fix sick people anytime soon. Here's why. Science, May.3,2016. http://www.sciencemag.org/news/2016/05/gene-editor-crispr-won-t-fully-fix-sick-people-anytime-soon-here-s-why
  [6] Liang P, Xu Y, Zhang X, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & Cell, 2015, 6(5):363-372.
  [7] Slaymaker I M, Gao L, Zetsche B, et al. Rationally engineered Cas9 nucleases with improved specificity. Science, 2015, 351,6268.
  [8] Erika Check Hayden. Should you edit your children's genes? Nature, 2016, February ,530, 402-405.http://www.nature.com/news/should-you-edit-your-children-s-genes-1.19432.
  [9] Julian Savulescu,Chris Gyngel,Tom Douglas.The Ethics of Gene Editing. 2015.http://petrieflom.law.harvard.edu/assets/publications/Savulescu_Gene_Editing_DRAFT.pdf.
  [10] Regalado A. Engineering the Perfect Baby. Mit Technology Review, 2015, 5:27-33. http://www.technologyreview.com/s/535661/engineering-the-perfect-baby.
  [11] David Baltimore, Paul Berg ,et al. A prudent path forward for genomic engineering and germline gene modification, Science,2015, 03:26-28.
  [12] R.Isasi,E.Kleiderman and B.M.Knoppers. Editing policy to fit the genome? Science, 2016, 22:337-339.http://science.sciencemag.org/content/351/6271/337.